Zombie Cancer Cells Eat Themselves to Live
April 5, 2014 · Comments Off on Zombie Cancer Cells Eat Themselves to Live
AACR 2014 study shows that the cellular process of autophagy in which cells "eat" parts of themselves in times of stress may allow cancer cells to recover and divide rather than die when faced with chemotherapies.
Study: Autophagy predicts which cancer cells live and die when faced with anti-cancer drugs
January 10, 2014 · Comments Off on Study: Autophagy predicts which cancer cells live and die when faced with anti-cancer drugs
When a tumor is treated with an anti-cancer drug, some cells die and, unfortunately, some cells tend to live. A University of Colorado Cancer Center study published in the journal Nature Cell Biology details a possible difference between the susceptible and resistant cells: the rate at which cells are able to cleanse themselves via the process known as autophagy.
AACR News: Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine
April 8, 2013 · Comments Off on AACR News: Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine
The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. And so it stands to reason that inhibiting autophagy would make cancer cells less able to cleanse themselves of chemotherapy and so more susceptible to the drugs. That's what the traditional anti-malaria drug, chloroquine, does – it inhibits autophagy. Existing clinical trials are testing chloroquine/chemotherapy combinations against breast cancer. Research presented at the AACR Annual Meeting 2013 shows that some breast cancer subtypes depend on autophagy more than others – and that inhibiting autophagy in breast cancers that depend on it may be enough alone to kill the disease.
Tightening the body’s cancer-catching net
November 30, 2012 · Comments Off on Tightening the body’s cancer-catching net
At CU Cancer Center, researchers, discover how dinosaurs, diabetes, Star Trek extras and Keith Richards combine to keep the body cancer-free.
Annual retreat shows the CU Cancer Center is greater than the sum of its parts
October 31, 2012 · Comments Off on Annual retreat shows the CU Cancer Center is greater than the sum of its parts
At the annual CU Cancer Center retreat on October 30, Deputy Director Andrew Thorburn, PhD,...
Getting down to business
June 21, 2012 · Comments Off on Getting down to business
Cancer Center Medical Director Tom Purcell brings corporate, medical experience By Todd Neff For a...
In my last glioblastoma grant application, I made the following statement: survival has barely moved...
Thorburn: Let’s blow our own trumpet more
November 3, 2011 · Comments Off on Thorburn: Let’s blow our own trumpet more
Last week, I visited the University of Pittsburgh Cancer Center to attend a couple of...
What I’m hoping for with these blogs is to stimulate debate about some of the...
January 10, 2017 · No comments
27 percent of heavily pretreated patients saw clinical benefit from the drug, with at least “stable disease” at 24 or more weeks after the start of treatment.
Crowdsourcing a better prostate cancer prediction tool
November 15, 2016 · Comments Off on Crowdsourcing a better prostate cancer prediction tool
Adding oxidative stress to FLT3 inhibition proves promising combination against AML
October 11, 2016 · Comments Off on Adding oxidative stress to FLT3 inhibition proves promising combination against AML
Double negative leads to big positive against bladder cancer metastasis
September 9, 2016 · Comments Off on Double negative leads to big positive against bladder cancer metastasis