Zombie Cancer Cells Eat Themselves to Live
April 5, 2014 · Comments Off on Zombie Cancer Cells Eat Themselves to Live
AACR 2014 study shows that the cellular process of autophagy in which cells "eat" parts of themselves in times of stress may allow cancer cells to recover and divide rather than die when faced with chemotherapies.
Study: Autophagy predicts which cancer cells live and die when faced with anti-cancer drugs
January 10, 2014 · Comments Off on Study: Autophagy predicts which cancer cells live and die when faced with anti-cancer drugs
When a tumor is treated with an anti-cancer drug, some cells die and, unfortunately, some cells tend to live. A University of Colorado Cancer Center study published in the journal Nature Cell Biology details a possible difference between the susceptible and resistant cells: the rate at which cells are able to cleanse themselves via the process known as autophagy.
AACR News: Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine
April 8, 2013 · Comments Off on AACR News: Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine
The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. And so it stands to reason that inhibiting autophagy would make cancer cells less able to cleanse themselves of chemotherapy and so more susceptible to the drugs. That's what the traditional anti-malaria drug, chloroquine, does – it inhibits autophagy. Existing clinical trials are testing chloroquine/chemotherapy combinations against breast cancer. Research presented at the AACR Annual Meeting 2013 shows that some breast cancer subtypes depend on autophagy more than others – and that inhibiting autophagy in breast cancers that depend on it may be enough alone to kill the disease.
Tightening the body’s cancer-catching net
November 30, 2012 · Comments Off on Tightening the body’s cancer-catching net
At CU Cancer Center, researchers, discover how dinosaurs, diabetes, Star Trek extras and Keith Richards combine to keep the body cancer-free.
Annual retreat shows the CU Cancer Center is greater than the sum of its parts
October 31, 2012 · Comments Off on Annual retreat shows the CU Cancer Center is greater than the sum of its parts
At the annual CU Cancer Center retreat on October 30, Deputy Director Andrew Thorburn, PhD,...
Getting down to business
June 21, 2012 · Comments Off on Getting down to business
Cancer Center Medical Director Tom Purcell brings corporate, medical experience By Todd Neff For a...
In my last glioblastoma grant application, I made the following statement: survival has barely moved...
Thorburn: Let’s blow our own trumpet more
November 3, 2011 · Comments Off on Thorburn: Let’s blow our own trumpet more
Last week, I visited the University of Pittsburgh Cancer Center to attend a couple of...
What I’m hoping for with these blogs is to stimulate debate about some of the...
April 25, 2016 · No comments
Eric Pietras, PhD, shows that chronic exposure to an inflammatory “emergency” signal, interleukin-1, causes blood-forming bone marrow stem cells to produce cells needed to fight infection and repair injury, but at the expense of their own ability to self-renew and maintain a healthy blood system.
Study: No escape from LOXO-101 for TRK-fusion lung cancer
April 17, 2016 · No comments
Study shows different genetic drivers of colorectal cancer in older and younger patients
January 21, 2016 · Comments Off on Study shows different genetic drivers of colorectal cancer in older and younger patients