All posts tagged james degregori

  • Evolution

    PNAS: Natural selection not just mutation drives development of cancer

    A paper published today in PNAS argues against the commonly held “accumulation of mutations” model of oncogenesis in favor of a model that depends on evolutionary pressures acting on populations of cells.

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Radiation
Math
Molecularly targeted therapies hold promise for many pediatric cancers, but at what cost? Image: Flickr/Cliff1066
Cancer-Catching Net
Changing tissue landscape and not necessarily accumulated oncogenic mutations drives higher cancer rates in the elderly. Image: Mick Jagger, cc license.
James DeGregori, Team In Training
Chemotherapy pushes AML cancer cells toward a corner -- the protein WEE1 helps them brake to stay on track. Take away WEE1 and AML cells hit the wall. (Photo courtesy of Flickr user ShinyThings, cc license.)
Cancer cells are like prarie dogs -- when a first-line cancer drug plugs the front dooor, cancer cells evolve to find other escapes. Photo courtesy of Flickr user gripso_banana_prune, CC license.