microRNA cooperation mutes breast cancer oncogenes
May 7, 2013 · Comments Off on microRNA cooperation mutes breast cancer oncogenes
“Imagine you have a microRNA that regulates genes A and B. Then you have another microRNA that regulates genes B and C. You amplify each microRNA to a degree that doesn’t effect gene A or C, but their combined effect regulates gene B,” says Bolin Liu, MD.
New marker of drug response may speed pace of lung cancer prevention trials
January 8, 2013 · Comments Off on New marker of drug response may speed pace of lung cancer prevention trials
Testing medicines to prevent lung cancer requires treating many thousands of high-risk individuals and then waiting 5, 10 or 15 years for results. A possible waypoint on the way to benefit may dramatically speed testing.
Serendipity points to new potential target and therapy for melanoma
December 20, 2012 · 2 comments
MicroRNA can decide which genes in a cell's DNA are expressed and which stay silent. Melanoma tends to lack microRNA-26a, which makes the gene SODD go silent. This silence creates cancer and may be instrumental in its cure.
MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
December 12, 2012 · Comments Off on MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
In medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low and by adding microRNA-218 to cells engineered to develop medulloblastoma, the development of the disease stopped.
MicroRNA makes triple-negative breast cancer homesick
November 21, 2012 · Comments Off on MicroRNA makes triple-negative breast cancer homesick
Like a sea monster, the programmed cell death known as anoikis attacks unprepared travelers -- in this case, cancer cells during metastasis
The making and unmaking of stem-like, aggressive breast cancer cells
August 9, 2012 · Comments Off on The making and unmaking of stem-like, aggressive breast cancer cells
Breast cancers that depend on the hormones estrogen and progesterone are susceptible to treatments targeting...
New grant funds collaborative effort to develop accurate, easy test to detect recurrence of ovarian cancer
October 17, 2011 · Comments Off on New grant funds collaborative effort to develop accurate, easy test to detect recurrence of ovarian cancer
The current test for the recurrence of ovarian cancer after treatment requires a blood draw...
April 25, 2016 · No comments
Eric Pietras, PhD, shows that chronic exposure to an inflammatory “emergency” signal, interleukin-1, causes blood-forming bone marrow stem cells to produce cells needed to fight infection and repair injury, but at the expense of their own ability to self-renew and maintain a healthy blood system.
Study: No escape from LOXO-101 for TRK-fusion lung cancer
April 17, 2016 · No comments
Study shows different genetic drivers of colorectal cancer in older and younger patients
January 21, 2016 · Comments Off on Study shows different genetic drivers of colorectal cancer in older and younger patients