All posts tagged microRNA

  • The sum of enhancing a few microRNAs may be greater than enhancing one by many, many times. Image: Flickr/Shoops2011

    microRNA cooperation mutes breast cancer oncogenes

    May 7, 2013 · Comments Off

    “Imagine you have a microRNA that regulates genes A and B. Then you have another microRNA that regulates genes B and C. You amplify each microRNA to a degree that doesn’t effect gene A or C, but their combined effect regulates gene B,” says Bolin Liu, MD.

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Subway.Map1

New marker of drug response may speed pace of lung cancer prevention trials
January 8, 2013 · Comments Off

Testing medicines to prevent lung cancer requires treating many thousands of high-risk individuals and then waiting 5, 10 or 15 years for results. A possible waypoint on the way to benefit may dramatically speed testing.

Melanoma-1

Serendipity points to new potential target and therapy for melanoma
December 20, 2012 · 2 comments

MicroRNA can decide which genes in a cell's DNA are expressed and which stay silent. Melanoma tends to lack microRNA-26a, which makes the gene SODD go silent. This silence creates cancer and may be instrumental in its cure.

Image: Flickr/Brewbooks

MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
December 12, 2012 · Comments Off

In medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low and by adding microRNA-218 to cells engineered to develop medulloblastoma, the development of the disease stopped.

Sea.Monster.Formatted

MicroRNA makes triple-negative breast cancer homesick
November 21, 2012 · Comments Off

Like a sea monster, the programmed cell death known as anoikis attacks unprepared travelers -- in this case, cancer cells during metastasis

Reverting to a stem-like state, as shown here, helps breast cancer cells evolve around the blockages of current treatments. Image: Flickr/CodonAUG cc license.

The making and unmaking of stem-like, aggressive breast cancer cells
August 9, 2012 · Comments Off

Breast cancers that depend on the hormones estrogen and progesterone are susceptible to treatments targeting...

New grant funds collaborative effort to develop accurate, easy test to detect recurrence of ovarian cancer
October 17, 2011 · Comments Off

The current test for the recurrence of ovarian cancer after treatment requires a blood draw...